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Evaluation of the anti-inflammatory drug indomethacin, for its genotoxicity in mice
Mutation Research
|August 1, 1987
Abstract:
Indomethacin, a non-steroidal anti-inflammatory drug was assessed for its genotoxicity in Swiss male mice employing bone marrow micronucleus induction, abnormal sperm formation and the induction of meiotic chromosome anomalies in spermatocytes as the test parameters. The results showed that the test compound was toxic to the genetic material in the dose range of 12-36 mg/kg body weight.
Insights
Indomethacin, a non-steroidal anti-inflammatory drug, showed toxicity to genetic material in male mice. This genotoxicity was observed at doses ranging from 12-36 mg/kg body weight in the study.
Area of Science:
- Pharmacology
- Toxicology
- Genetics
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used.
- Understanding the genotoxic potential of NSAIDs like indomethacin is crucial for safety assessment.
Purpose of the Study:
- To evaluate the genotoxicity of indomethacin in male mice.
- To assess the effects of indomethacin on genetic material using specific toxicological endpoints.
Main Methods:
- Swiss male mice were used as the model organism.
- Genotoxicity was assessed via bone marrow micronucleus induction.
- Abnormal sperm formation and meiotic chromosome anomalies in spermatocytes were also analyzed.
Main Results:
- Indomethacin demonstrated toxicity to the genetic material of the mice.
- The observed genotoxic effects occurred within the dose range of 12-36 mg/kg body weight.
Conclusions:
- Indomethacin exhibits genotoxic properties in vivo.
- The findings highlight the potential risk of indomethacin to genetic material at tested doses.