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Intercontinental Gut Microbiome Variances in IBD.
Luis Mayorga1,2,3, Gerard Serrano-Gómez1, Zixuan Xie1,2
1Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Geographic location and disease type significantly impact the gut microbiome in inflammatory bowel disease (IBD). Understanding these factors is crucial for developing globally applicable IBD biomarkers.
Area of Science:
- Microbiome research
- Gastroenterology
- Genomics
Background:
- Biomarkers for inflammatory bowel disease (IBD) diagnosis are needed.
- Intercontinental studies on microbial biomarkers for IBD are limited.
Purpose of the Study:
- To examine taxonomic microbiome variations in IBD across different geographical locations.
- To identify factors influencing microbial differences in Crohn's disease (CD) and ulcerative colitis (UC).
Main Methods:
- Utilized published DNA shotgun metagenomic data from Spanish, Chinese, and USA cohorts.
- Analyzed taxonomic and functional profiling tables.
- Assessed microbiome variations in relation to geography, disease phenotype, and severity.
Main Results:
- Geographical location and disease phenotype were primary drivers of microbiome variation globally.
- Geography was key in healthy controls (HC) and UC; intestinal location was key in CD.
- Disease severity correlated with lower alpha-diversity in UC, but not CD.
- CD patients across different countries showed similar microbial taxonomic profiles despite varying disease severity.
Conclusions:
- Geographic location, disease activity, and environmental factors significantly influence IBD-associated microbiota.
- Future IBD biomarker studies must consider these global factors for reproducibility and validity.
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