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Dual-Functional Nanofibrous Patches for Accelerating Wound Healing
Dan Xia1, Yuan Liu1, Wuxiu Cao1
1Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.
International Journal of Molecular Sciences
|September 23, 2022
Summary
This study developed a novel core-shell nanofiber membrane for wound healing. The dressing sequentially releases anti-bacterial and anti-inflammatory agents, accelerating wound repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Delayed wound healing is often caused by bacterial infections and inflammation.
- Advanced wound dressings are needed to manage these factors effectively.
- Coaxial electrospinning offers a method for controlled delivery of multiple therapeutic agents.
Purpose of the Study:
- To develop and characterize a core-shell nanofiber membrane for accelerated wound healing.
- To investigate the sequential release of anti-bacterial and anti-inflammatory agents.
- To evaluate the efficacy of the nanofiber membrane as a wound dressing.
Main Methods:
- Coaxial electrospinning of polycaprolactone (PCL) core loaded with curcumin (Cur) and a gelatin (GEL) shell loaded with tetracycline hydrochloride (TH).
- Characterization of fiber structure, water absorption, hydrophilicity, and mechanical properties.
- In vitro assessment of sequential drug release, antioxidant activity (DPPH assay), antibacterial efficacy (disk diffusion), and biocompatibility (human immortalized keratinocytes).
Main Results:
- Successfully fabricated PCL-Cur/GEL-TH core-shell nanofibers with desired structural and physical properties.
- Demonstrated sequential release of Cur and TH, indicating controlled drug delivery.
- Exhibited significant antioxidant and broad-spectrum antibacterial activities.
- Showed excellent biocompatibility with human keratinocytes.
Conclusions:
- The developed coaxial nanofiber membrane effectively co-delivers anti-bacterial and anti-inflammatory agents.
- This novel wound dressing shows great potential for promoting wound repair by addressing key healing barriers.
- The sequential release mechanism enhances therapeutic efficacy for advanced wound management.
