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A Differential Profile of Biomarkers between Patients with Atrial Fibrillation and Healthy Controls

Ana Merino-Merino1, Ruth Saez-Maleta2, Ricardo Salgado-Aranda1,3

  • 1Cardiology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain.

Journal of Personalized Medicine
|September 23, 2022
PubMed

Insights

Biomarkers like NT-proBNP, ST2, and high-sensitivity troponin T are elevated in patients with atrial fibrillation (AF). NT-proBNP showed the highest accuracy in differentiating AF patients from healthy individuals.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Atrial fibrillation (AF) involves anatomical and electrophysiological changes in the atria.
  • Myocardial inflammation, infiltration, and dilation contribute to AF pathogenesis.
  • Several biomarkers, including NT-proBNP, Hs-Tn, and ST2, are implicated in these processes.

Purpose of the Study:

  • To investigate differences in specific cardiac biomarkers between patients with persistent non-valvular AF and healthy controls.
  • To identify which biomarkers are most effective in distinguishing AF presence.

Main Methods:

  • A cross-sectional study design was employed.
  • 115 patients with persistent non-valvular AF undergoing electrical cardioversion were included.
  • 33 healthy subjects were recruited as controls.

Main Results:

  • Significantly elevated levels of NT-proBNP, ST2, and high-sensitivity troponin T (Hs-Tn T) were observed in AF patients compared to controls (p < 0.001 for all).
  • NT-proBNP demonstrated the highest diagnostic accuracy (AUC 0.995) for differentiating AF.
  • Optimal cut-off values were identified: NT-proBNP 102 pg/mL, Hs-Tn T 11.5 ng/L, and ST2 37.7 ng/mL.

Conclusions:

  • NT-proBNP, ST2, and Hs-Tn T are significantly associated with the presence of atrial fibrillation.
  • NT-proBNP is a highly effective biomarker for AF detection.
  • These biomarkers may play a role in the onset rather than the maintenance of AF.

Keywords:
NT-proBNPatrial fibrillationbiomarkers

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