Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estimating single-cell elastic modulus in a serial microfluidic cytometer from time-of-flight and fluorescence signals analysis.

Lab on a chip·2026

Same author

Geometrically Constrained Growth Factor Concentration Favors Enrichment of Goblet Cells and Mucus Formation.

ACS biomaterials science & engineering·2026

Same author

Development and characterisation of a radiobiology proton beamline using radiochromic film dosimetry.

Physics in medicine and biology·2026

Same author

Spatial Encoding with Amplitude Modulation in Serial Flow Cytometry.

Sensors (Basel, Switzerland)·2026

Same author

Single cell multiomic analysis of the impact of Delta-9-tetrahydrocannabinol on HIV infected CD4 T cells.

Journal of cannabis research·2026

Same author

An<i>in vitro</i>model of stiffened colonic mucosa exhibits altered epithelial behavior.

Biofabrication·2025

Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026

Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026

Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026

Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026

Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026

Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 27, 2025

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Published on: January 6, 2016

Scalable Additive Construction of Arrayed Microstructures with Encoded Properties for Bioimaging.

Matthew DiSalvo¹, Belén Cortés-Llanos^2,3, Cody A LaBelle²

¹Microsystems and Nanotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

|September 23, 2022

Summary

This summary is machine-generated.

A novel tool-free method enables additive batch construction of composite microstructures for microarrays. This technique simplifies fabrication, offering new possibilities for biosensing and cellular analysis applications.

Keywords:

barcoding bioimaging microarray analysis microfabrication single-cell analysis

More Related Videos

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Published on: April 11, 2025

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

Related Experiment Videos

Last Updated: Aug 27, 2025

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Published on: January 6, 2016

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Microfabrication of Implantable Optics Integrated in a Microstructured Imaging Window for Advanced In Vivo Imaging

Published on: April 11, 2025

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

Area of Science:

Materials Science
Biotechnology
Microfabrication

Background:

Microarrays are crucial for analytical instruments.
Traditional microfabrication methods hinder design and scalability of functional microarrays.
Composite materials offer enhanced functionalities but face fabrication challenges.

Purpose of the Study:

To develop a tool-free, additive fabrication technique for composite microstructures.
To overcome limitations of traditional microfabrication for microarray elements.
To demonstrate the versatility of the new method for creating functional microarrays.

Main Methods:

A tool-free, additive batch construction method using a carrier fluid and substrate topography.
Leveraging permutations of the basic approach for precise control over material volume and position.
Utilizing micromolding to create arrayed microstructures.

Main Results:

Successfully constructed micromolded, composite, and arrayed microstructures without specialized tools.
Demonstrated control over material deposition for varied designs and compositions.
Fabricated cell micro-carrier arrays as a proof of concept for diverse applications.

Conclusions:

The developed technique offers a scalable and versatile approach to fabricating composite microstructures.
This method simplifies the creation of complex biological and synthetic microelements.
Enables advancements in biosensing, cellular analysis, and biochemical screening platforms.