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LIMIT: LIfestyle and Microbiome InTeraction Early Adiposity Rebound in Children, a Study Protocol

Rachele De Giuseppe1, Federica Loperfido1, Rosa Maria Cerbo2

  • 1Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.

Metabolites
|September 23, 2022
PubMed

Insights

Early adiposity rebound (EAR) in children may be linked to early gut microbiome changes. This study explores the connection between infant gut microbes, lifestyle, and environmental factors to prevent childhood obesity.

Area of Science:

  • Pediatrics
  • Microbiome Research
  • Obesity Studies

Background:

  • Childhood obesity predicts adult obesity, posing significant health and economic burdens.
  • Adiposity rebound (AR) typically occurs between 3-7 years; early adiposity rebound (EAR) at ~2 years predisposes to later obesity.
  • Obesity is linked to intestinal dysbiosis, suggesting early microbiome alterations may influence EAR and its consequences.

Purpose of the Study:

  • To investigate the longitudinal relationship between infant gut microbiome, maternal/infant lifestyle, and environmental factors in children with EAR versus typical AR.
  • To identify modifiable maternal and infant factors for personalized childhood obesity prevention.

Main Methods:

  • Prospective cohort study of 272 mother-infant pairs from an Italian neonatal unit.
  • Data collected at multiple time points (delivery to 36 months postpartum).
  • Variables included maternal/infant anthropometrics, lifestyle, maternal endocrine disruptor exposure, and infant AR.

Main Results:

  • The study is ongoing, results are pending.
  • Analysis will focus on the interplay between gut microbiome, lifestyle, and environmental exposures in relation to EAR.
  • Identifying key factors for early intervention.

Conclusions:

  • Findings will form the basis for early identification of modifiable factors in maternal and infant health.
  • Aims to enable personalized prevention strategies for childhood obesity.
  • Understanding early microbiome changes is crucial for addressing obesity's health impacts.

Keywords:
childhood obesityearly adiposity reboundlifestylemicrobiomenutrition

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