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Published on: April 9, 2021
Fatty Acid-Binding Proteins in Psoriasis-A Review.
Julia Nowowiejska1, Anna Baran1, Iwona Flisiak1
1Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland.
Psoriasis, a common skin condition, involves lipid metabolism disruptions. Fatty-acid-binding proteins (FABPs) show altered levels in psoriasis, suggesting their role in disease severity and complications.
Area of Science:
- Dermatology
- Biochemistry
- Molecular Biology
Background:
- Psoriasis is a prevalent skin disease affecting 1-3% of the population.
- It is frequently associated with comorbidities, particularly metabolic syndrome.
- Fatty-acid-binding proteins (FABPs) are crucial in lipid metabolism and transport.
Purpose of the Study:
- To review the nature of all FABPs.
- To discuss the role of FABPs in psoriasis.
- To explore FABPs as potential biomarkers for psoriasis and its complications.
Main Methods:
- Literature review of existing studies on FABPs and psoriasis.
- Analysis of FABP expression and function in relation to psoriatic disease.
- Evaluation of FABPs as potential diagnostic or prognostic markers.
Main Results:
- Seven out of ten discovered FABPs have been investigated in psoriasis.
- Elevated concentrations of certain FABPs in psoriasis confirm its systemic nature.
- FABP-1 and FABP-5 show potential as markers for metabolic complications and inflammation.
- FABP-7 may indicate neurodegenerative processes in psoriatic patients.
Conclusions:
- FABPs play a significant role in the pathogenesis and systemic manifestations of psoriasis.
- Specific FABPs can serve as biomarkers for psoriasis-related comorbidities.
- Further research into FABPs could lead to novel diagnostic and therapeutic strategies for psoriasis.
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