Related Experiment Video
Updated: Jun 10, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Kailey A Wyman1, Adel S Girgis2, Pragnakiran S Surapaneni1,3
1Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Abstract:
We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates' selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.

