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Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

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Microfluidic Synthesis of -NH₂- and -COOH-Functionalized Magnetite Nanoparticles.

Cristina Chircov^1,2, Alexandra Cătălina Bîrcă^1,2, Bogdan Stefan Vasile^1,2,3

¹Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.

Nanomaterials (Basel, Switzerland)

|September 23, 2022

Summary

Microfluidics enables precise synthesis of functionalized magnetite nanoparticles (MNPs). This study optimized parameters for controlled nanoparticle properties, showing potential for biomedical applications.

Keywords:

amino carboxyl lab-on-chip magnetite nanoparticles microfluidics nanoparticle functionalization

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Area of Science:

Nanotechnology and Materials Science
Chemical Engineering
Biomedical Engineering

Background:

Microfluidics offers superior control over nanoparticle synthesis parameters.
Achieving uniform, reproducible, and easily integrated nanoparticle production is crucial.
Functionalized nanoparticles are essential for advanced biomedical applications.

Purpose of the Study:

To investigate the one-step microfluidic synthesis and functionalization of magnetite nanoparticles (MNPs).
To explore the influence of varying flow rates on nanoparticle characteristics.
To validate the microfluidic platform for producing tailored functionalized MNPs.

Main Methods:

One-step synthesis and functionalization of MNPs using sulfanilic acid and 4-sulfobenzoic acid in a microfluidic system.
Systematic variation of precursor and precipitating/functionalization solution flow rates.
Comprehensive characterization using DLS, zeta potential, XRD, SAED, TEM, HR-TEM, FT-IR, TG-DSC, and VSM.

Main Results:

Successful synthesis of magnetite as the sole mineralogical phase.
Demonstrated functionalization of the synthesized nanoparticles.
Confirmed control over crystallinity, size, shape, and functionalization degree by adjusting synthesis parameters.

Conclusions:

The microfluidic platform is effective for the one-step synthesis and functionalization of MNPs.
Tunable control over MNP properties is achievable by optimizing microfluidic parameters.
Developed functionalized MNPs are suitable for biomedical and pharmaceutical applications.