Related Experiment Video
Updated: Aug 27, 2025
06:26
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
1.2K
Redox-Responsive Drug Delivery Systems: A Chemical Perspective
Heba F Abed1, Waad H Abuwatfa2,3, Ghaleb A Husseini2,3
1Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Nanomaterials (Basel, Switzerland)
|September 23, 2022
Summary
Novel redox-responsive drug delivery systems offer a promising cancer treatment approach with targeted delivery and fewer side effects. Further research is needed to advance these systems for clinical cancer therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer poses a significant global health challenge, necessitating innovative treatments beyond conventional therapies with severe side effects.
- Current cancer treatments often lead to extensive systemic toxicity, highlighting the urgent need for safer and more effective therapeutic strategies.
- Redox-responsive drug delivery systems (DDSs) represent a promising avenue for cancer therapy, offering enhanced site-specific targeting and reduced off-target effects.
Purpose of the Study:
- To explore the tumor microenvironment's physiological and biochemical characteristics that enable redox-responsive drug delivery.
- To review recent advancements in the chemical composition and design of redox-responsive DDSs for cancer treatment.
- To identify key redox-responsive chemical entities and their application in various nanocarrier systems.
Main Methods:
- Review of literature on tumor physiology and biochemistry relevant to redox-responsive DDSs.
- Analysis of chemical entities utilized in redox-responsive DDSs, including disulfide bonds, diselenide bonds, succinimide-thioether linkages, tetrasulfide bonds, and platin conjugates.
- Examination of disulfide-containing nanocarriers such as liposomes, polymeric micelles, and nanogels.
Main Results:
- Tumor-specific redox environments can be exploited for targeted drug release.
- Disulfide bonds are the most frequently employed redox-responsive element in DDSs.
- Various nanocarrier platforms (liposomes, micelles, nanogels) incorporating disulfide bonds have been developed.
Conclusions:
- Redox-responsive DDSs demonstrate significant potential for targeted cancer therapy with improved efficacy and reduced toxicity.
- Further research and development are crucial to translate these advanced drug delivery systems into clinical applications for cancer treatment.
- The reviewed chemical entities and nanocarrier designs provide a foundation for future innovation in oncology drug delivery.
More Related Videos
09:57A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
8.9K
05:28Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
Published on: June 2, 2023
892
Related Concept Videos
01:24Redox Reactions
56.0K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
56.0K
01:23Redox Equilibria: Overview
618
A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
618
01:21Redox Titration: Overview
3.3K
Redox titration is a chemical analysis technique used to determine the concentration of an unknown substance by measuring the electron transfer in a redox (reduction-oxidation) reaction. The process involves gradually adding a titrant with a known concentration of an oxidizing or reducing agent, to the analyte, the solution with an unknown concentration, until reaching the endpoint, which indicates the completion of the reaction between the two substances. Ensuring the analyte is in a single...
3.3K
03:11Oxidation-Reduction Reactions
65.6K
Oxidation–Reduction Reactions
65.6K
01:19Oxidation and Reduction of Organic Molecules
7.1K
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
The removal of an electron from a molecule, results in a...
7.1K
01:17Oxidation of Phenols to Quinones
3.4K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.4K