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Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy.

Hui Wang1, Hai-Jun Wang1, Mingyuan Jiao2

  • 1Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Nutrients
|September 23, 2022
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Summary
This summary is machine-generated.

Optimal Vitamin D (VitD) status is crucial for pregnant women

Keywords:
Vitamin Ddeficiencyfree thyroxinefree triiodothyroninethyroid-stimulating hormone

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Nutritional Science

Background:

  • Optimal Vitamin D (VitD) status and thyroid function are vital for maternal and fetal health during pregnancy.
  • Pregnancy involves dynamic physiological changes affecting both VitD levels and thyroid hormone regulation.
  • Existing research highlights the importance of VitD and thyroid function, but dynamic associations throughout pregnancy require further elucidation.

Purpose of the Study:

  • To investigate the associations between dynamic Vitamin D (VitD) status and key thyroid function parameters across each trimester of pregnancy.
  • To analyze these associations throughout the entire pregnancy period using a large retrospective cohort.
  • To provide evidence-based recommendations for maintaining adequate VitD levels to support thyroid health in pregnant individuals.

Main Methods:

  • Retrospective analysis of data from 8828 pregnant women in the Peking University Retrospective Birth Cohort.
  • Dynamic VitD status was defined by combinations of deficiency/sufficiency in the first and second trimesters.
  • Thyroid function parameters (TSH, fT4, fT3) were assessed across three trimesters.
  • Statistical analyses included multiple linear regression and generalized estimating equation models.

Main Results:

  • Positive associations were observed between VitD status and free thyroxine (fT4) and free triiodothyronine (fT3) in the first trimester.
  • Pregnant individuals with VitD sufficiency in the first trimester and deficiency in the second trimester showed lower TSH levels compared to those sufficient in both trimesters.
  • These associations between VitD and thyroid function parameters were significant throughout the pregnancy period.

Conclusions:

  • Vitamin D (VitD) status and thyroid function are interconnected throughout pregnancy.
  • Maintaining adequate VitD levels is critical for supporting optimal thyroid function in pregnant women.
  • These findings underscore the importance of monitoring and ensuring sufficient VitD status during pregnancy to promote maternal and fetal well-being.