Related Experiment Video

Updated: Aug 27, 2025

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.3K

Characteristics of COVID-19 Infection in a Hospitalized Autoimmune Hepatitis Patient

Vanessa Duarte da Costa1, Wilian Jean Wiggers2, Claudia Alexandra Pontes Ivantes2

  • 1Brazilian Reference Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil.

Pathogens (Basel, Switzerland)
|September 23, 2022
PubMed

Insights

This case report examines how immunosuppressive therapy in autoimmune hepatitis patients may affect COVID-19 outcomes. It highlights potential influences on clinical course and lab results during SARS-CoV-2 infection.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Immunology

Background:

  • The COVID-19 pandemic caused by SARS-CoV-2 presents challenges in managing patients with pre-existing conditions.
  • Hepatic dysfunction is a recognized complication of COVID-19, with multifactorial causes.
  • Optimal management of immunosuppressive therapy in autoimmune hepatitis (AIH) patients during SARS-CoV-2 infection is not well-established.

Observation:

  • This report details a case of an autoimmune hepatitis patient with COVID-19.
  • The patient was undergoing treatment with immunosuppressive drugs.
  • Alterations in hematological and biochemical parameters were observed during the SARS-CoV-2 infection.

Findings:

  • The use of immunosuppressive therapy in this AIH patient potentially influenced the clinical course of their COVID-19 infection.
  • Specific laboratory parameters, including hematological and biochemical markers, showed changes during the infection.

Implications:

  • This case suggests that immunosuppressive drug use in AIH patients may impact COVID-19 presentation and progression.
  • Further research is needed to guide recommendations for modifying immunosuppressive therapy in AIH patients with SARS-CoV-2 infection.
  • Understanding these interactions is crucial for managing complex patient cases during pandemics.

Keywords:
COVID-19SARS-CoV-2autoimmune hepatitis

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.5K

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
19
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
625
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
13
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
481
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
299
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
19