Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental spinal epidural abscess: a pathophysiological model in the rabbit.

J A Feldenzer, P E McKeever, D R Schaberg

    Neurosurgery
    |June 1, 1987
    PubMed
    Summary

    This study models spinal epidural abscesses in rabbits, revealing direct compression causes neurological deficits and white matter damage, not infarction. The findings mimic spinal cord compression from tumors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comment on: Bariatric surgery is expensive but improves co-morbidity: 5-year assessment of patients with obesity and type 2 diabetes.

    The British journal of surgery·2021
    Same author

    Relationship between adverse childhood experiences and perceived discrimination in adulthood.

    Journal of affective disorders·2020
    Same author

    Letters to the Editor.

    Nutrition reviews·2019
    Same author

    The differential impact of adverse childhood experiences in the development of pre-diabetes in a longitudinal cohort of US adults.

    Journal of diabetes and its complications·2018
    Same author

    Diverse approaches to the health economic evaluation of bariatric surgery: a comprehensive systematic review.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2016
    Same author

    A five year follow-up of coloured children with kwashiorkor in Cape Town.

    Journal of tropical pediatrics (London, England : 1955)·2014

    Area of Science:

    • Neurology
    • Pathophysiology
    • Experimental Medicine

    Background:

    • Spinal epidural abscesses (SEA) can cause severe neurological deficits.
    • The exact pathophysiology of SEA-induced spinal cord dysfunction requires further elucidation.

    Purpose of the Study:

    • To establish an experimental model for defining the pathophysiology of spinal cord dysfunction in SEA.
    • To investigate the effects of SEA on spinal cord tissue and neurological function.

    Main Methods:

    • An experimental model of SEA was created in rabbits by injecting Staphylococcus aureus into the epidural space.
    • Neurological deficits, plain spine radiography, myelography, and cerebrospinal fluid analysis were performed.
    • Histopathological examination of spinal cords was conducted.

    Related Experiment Videos

    Main Results:

    • 18 of 20 rabbits developed progressive neurological deficits, including paraparesis/paraplegia (75%) and sphincter dysfunction (55%).
    • Pathological confirmation of spinal cord compression by epidural abscesses was observed in 95% of cases.
    • Spinal cord white matter showed vacuolization, myelin loss, and axonal swelling, consistent with direct compression rather than infarction.

    Conclusions:

    • Direct compression by spinal epidural abscesses is the primary cause of spinal cord dysfunction.
    • The observed histopathological changes resemble those seen in spinal cord compression due to epidural neoplasms.
    • This model provides insights into the pathophysiology of neurological deficits associated with SEA.