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Updated: Aug 27, 2025

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
Fucheng Leng1, Oleksii Shemchuk1, Koen Robeyns1
1Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, 1 Place Louis Pasteur, B-1348 Louvain-La-Neuve, Belgium.
Abstract:
Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms.
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