Preparation and Optimization of Ibrutinib-Loaded Nanoliposomes Using Response Surface Methodology

Area of Science:

• Pharmaceutical Nanotechnology
• Drug Delivery Systems
• Materials Science

Background:

• Ibrutinib is a crucial drug for treating certain cancers.
• Developing effective nanoliposomal formulations enhances drug delivery and therapeutic efficacy.
• Optimization of formulation and process parameters is key for reproducible nanoliposome production.

Purpose of the Study:

• To optimize the formulation and process variables for ibrutinib nanoliposomes.
• To evaluate the stability of the optimized ibrutinib nanoliposomes.
• To establish a reliable method for preparing high-quality ibrutinib nanoliposomes.

Main Methods:

• Response surface methodology (RSM) was employed to investigate the influence of formulation and process parameters.
• Reverse-phase evaporation technique was used for nanoliposome preparation.
• Multiple linear regression and numerical optimization were utilized to determine optimal conditions.

Main Results:

• The phosphatidylcholine-to-cholesterol ratio significantly impacted drug encapsulation efficiency.
• All investigated factors influenced nanoliposome particle size.
• Optimal conditions yielded 90.76% encapsulation efficiency and 208.24 nm particle size.
• Nanoliposomes demonstrated stability in simulated gastric and intestinal fluids at 37°C for 6 hours.

Conclusions:

• The optimization technique reliably produced ibrutinib nanoliposomes with improved characteristics.
• Optimized ibrutinib nanoliposomes show potential for enhanced drug delivery.
• Formulation and process parameters are critical for achieving desired nanoliposome attributes and stability.