Bioabsorbable Carboxymethyl Starch-Calcium Ionic Assembly Powder as a Hemostatic Agent

Area of Science:

• Biomaterials Science
• Hemostasis Research
• Surgical Innovation

Background:

• Hemostatic powders offer advantages for complex bleeding sites but suffer from desorption.
• Reduced desorption is critical for maintaining hemostatic efficacy.

Purpose of the Study:

• To investigate the hemostatic performance of a novel bioabsorbable powder (OOZFIXTM) with reduced desorption.
• To compare OOZFIXTM with a commercial carboxymethyl starch-based hemostatic powder (AristaTM AH).

Main Methods:

• Characterization of OOZFIXTM microstructure and chemical properties.
• Evaluation of hemostatic performance: blood absorption, absorption rate, coagulation time, TEG, rheology, adhesion, and C3a activation.
• In vivo assessment using a rat hepatic hemorrhage model.

Main Results:

• OOZFIXTM demonstrated significantly faster hemostasis (78 ± 17 s) compared to AristaTM AH (182 ± 11 s) in vivo.
• Reduced desorption of OOZFIXTM was confirmed as the key factor for improved efficacy.
• Quick biodegradation of OOZFIXTM (<3 weeks) was observed.

Conclusions:

• OOZFIXTM exhibits superior hemostatic performance due to decreased desorption.
• The bioabsorbable hemostatic powder shows promise for precise surgical applications.
• OOZFIXTM represents a significant advancement in hemostatic agent technology.