Modulation of auditory evoked magnetic fields by benzodiazepines

The N1 and P2 components of the auditory evoked magnetic field were shown to be modified by the benzodiazepines diazepam and triazolam. Previous studies indicate that the electrical sources of these components are located in the auditory cortex, implying that benzodiazepines have a direct or indirect effect on neuronal activity at this level. The recorded changes were comparable to those previously reported using auditory evoked potential measurements. These results suggest that magnetic recordings may eventually be used as a sensitive, supplementary and location-specific measure of the central action of psychoactive substances.