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High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating.

Junlan Zhong1,2, Shen Liu1,2, Tao Zou1,2

  • 1Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Sensors (Basel, Switzerland)
|September 23, 2022
PubMed
Summary

A novel helical intermediate-period fiber grating (HIPFG) was developed for fiber optic glucose sensing. This sensor offers high sensitivity and stability, with potential for compact, long-term biosensing applications.

Keywords:
glucose detectionhelical intermediate-period fiber gratingoptical fiber sensor

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Area of Science:

  • Photonics and Optical Sensing
  • Biomedical Engineering
  • Materials Science

Background:

  • Accurate glucose monitoring is crucial for diabetes management.
  • Existing glucose sensors face challenges in sensitivity, stability, and temperature compensation.
  • Fiber optic sensors offer advantages like remote sensing and immunity to electromagnetic interference.

Purpose of the Study:

  • To propose and demonstrate an all-fiber glucose sensor based on a helical intermediate-period fiber grating (HIPFG).
  • To evaluate the sensor's performance in terms of refractive index sensitivity, temperature sensitivity, and glucose detection capabilities.
  • To assess the sensor's stability for potential long-term monitoring.

Main Methods:

  • Fabrication of HIPFG using hydrogen/oxygen flame heating.
  • Characterization of the HIPFG's transmission spectrum, refractive index (RI) sensitivity, and temperature sensitivity.
  • Testing the sensor's performance for glucose detection, including sensitivity and limit of detection (LOD).

Main Results:

  • The HIPFG exhibited four sets of double dips with low insertion losses and strong coupling.
  • High average RI sensitivity of 213.6 nm/RIU and a maximum sensitivity of 472 nm/RIU were achieved.
  • Low-temperature sensitivity of 3.67 pm/°C demonstrated self-temperature compensation.
  • Glucose detection sensitivity of 0.026 nm/(mg/mL) and an LOD of 1 mg/mL were obtained.
  • The sensor showed good stability over a 2-hour period.

Conclusions:

  • The developed HIPFG is a promising platform for sensitive and stable glucose sensing.
  • The sensor's self-temperature compensation and good stability are advantageous for practical applications.
  • The easy fabrication, flexibility, and compact nature of the HIPFG sensor suggest potential for long-term biosensing.