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Updated: Aug 27, 2025
Viral Nanoparticles for In vivo Tumor Imaging
Published on: November 16, 2012
Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
Mehdi Shahgolzari1, Hassan Dianat-Moghadam2, Afagh Yavari3
1Dental Research Center, Hamadan University of Medical Sciences, Hamadan 6517838636, Iran.
Abstract:
Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms.
Insights
Plant-virus-based nanoparticles (PVNPs) show promise in preclinical breast cancer treatment, offering targeted delivery of therapies and immune agents for enhanced antitumor responses.
Area of Science:
- Biotechnology
- Nanomedicine
- Oncology
Background:
- Plant-virus-based nanoparticles (PVNPs) are emerging as effective platforms in preclinical breast cancer research.
- PVNPs offer versatile nanocarrier systems for drug delivery and immunotherapy.
Purpose of the Study:
- To review current breast cancer treatments utilizing PVNP platforms.
- To highlight the potential of PVNPs in delivering therapeutic agents and activating antitumor immunity.
Main Methods:
- Review of preclinical studies on PVNP-based breast cancer therapies.
- Analysis of PVNP applications in targeted and non-targeted drug delivery.
- Examination of PVNP use in cancer vaccines and combination therapies.
Main Results:
- PVNPs demonstrate success in preclinical breast cancer models.
- PVNP platforms can encapsulate diverse therapeutic agents and targeting ligands.
- Combination of PVNPs with other therapies enhances treatment efficacy.
Conclusions:
- PVNP platforms represent a promising strategy for advanced breast cancer treatment.
- Targeted delivery and immune activation are key benefits of PVNP-based therapies.
- Further research into PVNP applications could significantly impact oncotherapy.
