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Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies

Chen Cai1,2, Feng Wu1,2, Jing He1,2

  • 1Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

International Journal of Biological Sciences
|September 23, 2022
PubMed

Insights

Diabetic cardiomyopathy (DCM) involves mitochondrial dysfunction and impaired mitochondrial quality control (MQC). Targeting MQC offers a promising therapeutic strategy to prevent DCM progression and improve patient outcomes.

Area of Science:

  • Cardiology
  • Mitochondrial Biology
  • Diabetology

Background:

  • Diabetic cardiomyopathy (DCM) is a severe complication of diabetes, characterized by cardiac structural and functional changes.
  • Current treatments for DCM are limited, leading to a poor prognosis.
  • Mitochondrial dysfunction is a key driver of DCM pathogenesis, affecting cardiomyocyte energy production and cellular processes.

Purpose of the Study:

  • To review the molecular mechanisms of mitochondrial quality control (MQC) in the context of DCM.
  • To elucidate how pathological MQC contributes to the development and progression of DCM.
  • To explore novel therapeutic strategies targeting MQC for DCM prevention and treatment.

Main Methods:

  • Literature review of molecular mechanisms underlying MQC.
  • Analysis of the role of mitochondrial fission, fusion, and mitophagy in DCM.
  • Discussion of therapeutic interventions aimed at restoring MQC.

Main Results:

  • Abnormal MQC, including excessive fission, impaired fusion, and delayed mitophagy, leads to accumulation of damaged mitochondria in cardiomyocytes.
  • This mitochondrial fragmentation exacerbates DCM by promoting oxidative stress, calcium dysregulation, and apoptosis.
  • Restoring physiological MQC presents a potential therapeutic avenue for DCM.

Conclusions:

  • Pathological MQC is a critical factor in DCM development.
  • Therapeutic strategies enhancing MQC, such as promoting mitophagy and balancing fission/fusion, hold promise for treating DCM.
  • Further research into MQC modulation could lead to effective DCM therapies.

Keywords:
Diabetic cardiomyopathymitochondrial fissionmitochondrial fusionmitochondrial quality controlmitophagy

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