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Updated: Aug 27, 2025

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions
Ye Zhang1, Ran Guo2, Shan-Shan Wang1
1College of Basic Medical Science, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning Province, P. R. China.
Abstract:
It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.
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