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Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

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Recent advances in engineering nanotopographic substrates for cell studies.

Ignasi Casanellas^1,2,3, Josep Samitier^1,2,3, Anna Lagunas^1,3

¹Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

Frontiers in Bioengineering and Biotechnology

|September 23, 2022

Summary

Engineered cell culture substrates with nanoscale features guide cell responses by interacting with cell membrane receptors. This overview covers biological context, fabrication methods, and applications of these advanced materials.

Keywords:

cell response nanofabrication nanopatterning nanotopography receptor nanoclustering

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Area of Science:

Cell biology
Materials science
Biotechnology

Background:

Cells interact with their environment via cell membrane receptors, which cluster upon ligand binding.
Receptor nanoclusters organize hierarchically, influencing cell signaling and response.
Engineered cell culture substrates offer tools to control cell behavior at various scales.

Purpose of the Study:

To provide an overview of cell response modulation using engineered substrates.
To summarize recent advancements in nanoscale material-cell interactions.
To highlight substrate fabrication techniques and their applications.

Main Methods:

Review of existing literature on cell-material interactions.
Analysis of nanoscale (1-100 nm) substrate features for receptor engagement.
Discussion of fabrication techniques for engineered cell culture substrates.

Main Results:

Nanoscale substrate features enable direct interaction with single cell receptors and nanoclusters.
Hierarchical organization of receptors on substrates influences biological functions.
Contact guidance principles have evolved with increasing feature resolution.

Conclusions:

Engineered substrates, particularly those with nanoscale features, are crucial for studying and controlling cell responses.
Advancements in fabrication techniques continue to expand the applications of these materials.
Understanding cell-material interactions at the nanoscale is key for future biological and biomedical applications.