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Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
Published on: November 18, 2019
Targeting oxidative phosphorylation as an approach for the treatment of ovarian cancer
Yinjie Wu1, Xuewei Zhang1, Ziyi Wang2
1Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Abstract:
Ovarian cancer is an aggressive tumor that remains to be the most lethal gynecological malignancy in women. Metabolic adaptation is an emerging hallmark of tumors. It is important to exploit metabolic vulnerabilities of tumors as promising strategies to develop more effective anti-tumor regimens. Tumor cells reprogram the metabolic pathways to meet the bioenergetic, biosynthetic, and mitigate oxidative stress required for tumor cell proliferation and survival. Oxidative phosphorylation has been found to be altered in ovarian cancer, and oxidative phosphorylation is proposed as a therapeutic target for management of ovarian cancer. Herein, we initially introduced the overview of oxidative phosphorylation in cancer. Furthermore, we discussed the role of oxidative phosphorylation and chemotherapeutic resistance of ovarian cancer. The role of oxidative phosphorylation in other components of tumor microenvironment of ovarian cancer has also been discussed.
Insights
Ovarian cancer cells alter oxidative phosphorylation for survival. Targeting this metabolic pathway offers a promising strategy for new anti-cancer treatments against this lethal gynecological malignancy.
Area of Science:
- Oncology
- Cancer Metabolism
- Gynecologic Oncology
Background:
- Ovarian cancer is a leading cause of cancer death in women.
- Tumor cells exhibit metabolic adaptation, reprogramming pathways for growth and survival.
- Oxidative phosphorylation is a key metabolic process altered in various cancers.
Purpose of the Study:
- To provide an overview of oxidative phosphorylation in cancer.
- To discuss the role of oxidative phosphorylation in ovarian cancer and its chemotherapeutic resistance.
- To explore the impact of oxidative phosphorylation on the ovarian cancer tumor microenvironment.
Main Methods:
- Literature review and synthesis of existing research on oxidative phosphorylation in cancer.
- Analysis of the role of oxidative phosphorylation in ovarian cancer progression and drug resistance.
- Examination of oxidative phosphorylation's influence on the tumor microenvironment.
Main Results:
- Oxidative phosphorylation is significantly altered in ovarian cancer cells.
- Dysregulated oxidative phosphorylation contributes to ovarian cancer's aggressive nature and resistance to chemotherapy.
- Oxidative phosphorylation impacts various components within the ovarian cancer tumor microenvironment.
Conclusions:
- Altered oxidative phosphorylation represents a critical metabolic vulnerability in ovarian cancer.
- Targeting oxidative phosphorylation presents a promising therapeutic strategy for ovarian cancer treatment.
- Further research into oxidative phosphorylation's role could lead to more effective anti-cancer regimens.
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