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Case report: Open bite as an extrapyramidal side effect with aripiprazole, a dopamine partial agonist
Satoko Sumi1, Takahiko Nagamine2,3, Koji Sumi4
1Section of Pediatric Dentistry, Department of Oral Growth and Development, Fukuoka Dental College, Fukuoka, Japan.
Frontiers in Psychiatry
|September 23, 2022
Summary
Aripiprazole use in children and adolescents may cause or worsen open bite malocclusion due to extrapyramidal symptoms. Dosage adjustments can improve this dental side effect.
Area of Science:
- Dentistry
- Pharmacology
- Orthodontics
Background:
- Open bite is a malocclusion affecting dental alignment and function.
- Aripiprazole is a medication sometimes prescribed for children and adolescents.
- Understanding drug-induced side effects is crucial in managing patient health.
Observation:
- Long-term patient observation revealed a correlation between aripiprazole dosage and open bite.
- Open bite severity increased with higher aripiprazole doses.
- Open bite improved as aripiprazole dosage was reduced.
Findings:
- Extrapyramidal symptoms associated with aripiprazole dosage appear to cause or exacerbate open bite malocclusion.
- This suggests a direct link between the medication and the observed dental changes.
Implications:
- Physicians must consider the risk of open bite when prescribing aripiprazole to pediatric patients.
- Dentists should inquire about medication history, specifically aripiprazole use, when treating open bite in young patients.
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