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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report

Francesco Colombo1, Ali Waheed1, Sandro Panese2

  • 1Department of Molecular Medicine, University of Padova, Padua, Italy.

Le Infezioni in Medicina
|September 23, 2022
PubMed

Insights

Cefiderocol successfully treated meningitis caused by carbapenemase-producing Klebsiella pneumoniae (CPKP) resistant to ceftazidime/avibactam. This case highlights cefiderocol as a crucial option for challenging CPKP infections.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Pharmacology

Background:

  • Carbapenemase-producing Klebsiella pneumoniae (CPKP) presents a significant global health threat due to limited treatment options.
  • Post-surgical meningitis requires prompt and effective antimicrobial therapy to prevent severe neurological sequelae.

Observation:

  • A 44-year-old male patient developed meningitis due to CPKP following surgery.
  • Initial treatment with ceftazidime/avibactam (CZA) plus fosfomycin and linezolid showed initial response but was complicated by CZA-resistant CPKP isolation from cerebrospinal fluid (CSF).

Findings:

  • Cerebrospinal fluid (CSF) cultures confirmed a ceftazidime/avibactam resistant Klebsiella pneumoniae strain.
  • Successful treatment was achieved using cefiderocol (FDC) combined with trimethoprim/sulfamethoxazole for 14 days, alongside external ventricular drainage (EVD) management.

Implications:

  • This case report is the first to describe the successful use of cefiderocol in treating CPKP meningitis.
  • Cefiderocol demonstrates potential as a valuable therapeutic agent for complex CPKP infections, particularly in cases of resistance to other agents.
Keywords:
Klebsiella pneumoniaecarbapenemasecefiderocolenterobacteralesmeningitidis

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