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Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis
Liwei Cheng1, Fan Zhang2, Ying Wang3
1Office of Academic Research, Renmin Hospital of Wuhan University, Wuhan, China.
This meta-analysis reveals that specific Interferon-gamma Receptor 1 (IFNGR1) gene variations are linked to tuberculosis (TB) susceptibility. Certain polymorphisms show differing associations with TB risk across African and Asian populations.
Area of Science:
- Genetics
- Immunology
- Infectious Diseases
Background:
- Tuberculosis (TB) remains a global health challenge.
- The role of Interferon-gamma Receptor 1 (IFNGR1) gene polymorphisms in TB susceptibility requires systematic investigation.
Purpose of the Study:
- To conduct a comprehensive meta-analysis assessing the association between IFNGR1 gene polymorphisms and tuberculosis susceptibility.
Main Methods:
- Systematic literature search across major databases (PubMed, EMBASE, Web of Science, Cochrane Library).
- Meta-analysis of fourteen studies including 7,699 TB cases and 8,289 controls.
- Statistical analysis using random-effect models and STATA 12.0 software.
Main Results:
- IFNGR1 rs2234711 polymorphism associated with increased TB susceptibility in Africans (dominant model) and decreased susceptibility in Asians (allele, homozygote, additive models).
- IFNGR1 rs7749390 polymorphism associated with decreased TB susceptibility in Africans (allele model).
- No significant association found for IFNGR1 rs1327474 polymorphism with TB susceptibility.
Conclusions:
- IFNGR1 gene polymorphisms, specifically rs2234711 and rs7749390, show significant associations with tuberculosis susceptibility.
- These associations vary by ethnicity, highlighting the complex genetic underpinnings of TB.
- Further research into IFNGR1's role in TB pathogenesis is warranted.
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