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Updated: Aug 27, 2025
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
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Outcome after bilateral deep vein thrombosis
Aline Fürbringer-Schwarz1, Marie Janscak2, Christina R Jeanneret-Gris3
1Department of Angiology, University Hospital Zurich, University of Zurich, Switzerland.
VASA. Zeitschrift Fur Gefasskrankheiten
|September 23, 2022
Summary
Bilateral deep vein thrombosis (DVT) affects 19% of patients and is linked to higher cancer and pulmonary embolism rates. Patients with bilateral DVT are older and have increased mortality, but recurrence rates are similar to unilateral cases.
Area of Science:
- Vascular Medicine
- Oncology
- Epidemiology
Background:
- Deep vein thrombosis (DVT) is a significant vascular condition.
- Understanding the prevalence and implications of bilateral DVT is crucial for patient outcomes.
Purpose of the Study:
- To determine the incidence of bilateral deep vein thrombosis (DVT).
- To investigate the association between bilateral DVT and cancer, pulmonary embolism, and mortality.
- To assess the impact of bilateral DVT on thromboembolic disease recurrence.
Main Methods:
- Retrospective analysis of 2409 DVT patient records from 2000-2017.
- Follow-up questionnaire for 755 patients assessing thromboembolic recurrence, malignancy, and pulmonary embolism.
- Nonparametric tests used for two-group comparisons between unilateral and bilateral DVT cohorts.
Main Results:
- Bilateral DVT occurred in 19% of the study cohort.
- Patients with bilateral DVT had significantly higher rates of cancer (22.5% vs. 15.4%) and pulmonary embolism (33.8% vs. 20.8%).
- Bilateral DVT patients were older (median 69 vs. 63 years) and exhibited higher mortality (9.1% vs. 5.2%).
Conclusions:
- Bilateral DVT is more prevalent than previously reported.
- Bilateral DVT is associated with increased risks of malignancy and pulmonary embolism.
- Older age and higher mortality are observed in patients with bilateral DVT, though recurrence rates were not significantly different.
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