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Neurological post-acute sequelae of SARS-CoV-2 infection
Masaki Takao1, Masayuki Ohira1
1Department of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Tokyo, Japan.
Psychiatry and Clinical Neurosciences
|September 23, 2022
Summary
Post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID-19, presents diverse neurological and psychiatric symptoms. Current diagnostic and treatment strategies for PASC remain limited, necessitating further research and clinical guidance.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- COVID-19, caused by SARS-CoV-2, can lead to acute and chronic phases with various neurological and psychiatric symptoms.
- Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID-19, encompasses a broad range of persistent symptoms.
- PASC symptoms include fatigue, dyspnea, cognitive dysfunction, and mental health issues, affecting up to 50% of patients for 12 months post-infection.
Approach:
- This review synthesizes current information on PASC, focusing on neurological sequelae.
- It discusses the challenges in diagnosing PASC due to unclear pathophysiology and broad definitions.
- Clinical suggestions for PASC diagnosis and patient care are provided based on outpatient experience.
Key Points:
- PASC involves a wide spectrum of neurological and psychiatric symptoms following COVID-19.
- The pathophysiology of PASC is not fully understood, leading to diagnostic and therapeutic challenges.
- Neurological manifestations of PASC require focused clinical attention and management strategies.
Conclusions:
- Accurate diagnosis of PASC is difficult due to the lack of defined criteria and understanding of its mechanisms.
- Effective treatments for PASC are still under development, highlighting the need for ongoing research.
- This review aims to guide clinicians in managing patients experiencing neurological sequelae of COVID-19.
