Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

628
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
628
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

231
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
231
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

210
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
210
Drug Dependence01:17

Drug Dependence

1.1K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.1K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

334
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
334
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

432
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
432

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum fibroblast growth factor-2 and fibroblast growth factor-9 levels in bipolar disorder: Potential biomarkers for mood episodes.

Psychiatry research·2026
Same author

Serum zonulin, brain-derived neurotrophic factor, and oxidative stress levels in individuals using paper (A4) impregnated with synthetic cannabinoids.

Frontiers in psychiatry·2025
Same author

Bruxism and Sleep Disorders in Patients Diagnosed With Depressive Disorder and Anxiety Disorder Using Antidepressants.

Journal of oral rehabilitation·2024
Same author

Comparative evaluation of craving, sleep quality, sexual function and quality of life in opioid use disorder patients in remission with buprenorphine/naloxone maintenance treatment.

Human psychopharmacology·2024
Same author

A Self-Management App for Patients with Schizophrenia: A Pilot Study.

Studies in health technology and informatics·2022
Same author

Comparison of naltrexone implant and oral buprenorphine-naloxone in the treatment of opiate use disorder.

Human psychopharmacology·2021

Related Experiment Video

Updated: Aug 27, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

9.8K

Doxylamine Addiction: A Case Report.

Asena Uzdu Yaşar, Buket Cinemre

    Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry
    |September 23, 2022
    PubMed
    Summary

    This case report details a 43-year-old male with a 5-year history of doxylamine succinate dependence, highlighting the abuse potential of this common over-the-counter antihistamine used for insomnia.

    Area of Science:

    • Pharmacology
    • Addiction Psychiatry

    Background:

    • Doxylamine succinate is an over-the-counter antihistamine commonly prescribed for insomnia.
    • While antihistamines have known abuse potential, specific research on doxylamine succinate addiction is limited.

    Observation:

    • A case report of a 43-year-old male patient with a 5-year history of uninterrupted doxylamine succinate use is presented.
    • The patient escalated daily dosage from 25 mg to 125 mg for insomnia management.
    • This represents the first reported case of doxylamine succinate addiction in Turkey.

    Findings:

    • The case illustrates the potential for drug dependence with doxylamine succinate, even when used as prescribed for insomnia.
    • Long-term, high-dose use can lead to significant substance abuse issues.

    More Related Videos

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    993
    Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
    05:59

    Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

    Published on: October 20, 2023

    2.5K

    Related Experiment Videos

    Last Updated: Aug 27, 2025

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
    10:17

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

    Published on: April 23, 2019

    9.8K
    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    993
    Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
    05:59

    Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

    Published on: October 20, 2023

    2.5K

    Implications:

    • Highlights the need for increased awareness regarding the abuse potential of widely available antihistamines like doxylamine succinate.
    • Suggests further research into the addictive properties of doxylamine succinate and the development of safer alternatives for insomnia treatment.