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Usefulness of C-Reactive Protein and Clinical Characteristics in Identifying Severe Bacterial Infection in Children

Jefferson Antonio Buendia Rodriguez1, Marisela Bedoya2, Dione Benjumea2

  • 1Department of Pharmacology and Toxicology, University of Antioquia Faculty of Medicine, Bello, Colombia.

Turkish Archives of Pediatrics
|September 23, 2022
PubMed

Insights

Most infants with fever without source have self-limiting illnesses. High C-reactive protein and longer fever duration can indicate serious bacterial infections in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Clinical Diagnostics

Background:

  • Fever is a common pediatric concern, often leading to extensive testing.
  • Refining diagnostic strategies for fever without source is crucial, especially in resource-limited settings.

Purpose of the Study:

  • To determine the prevalence of serious bacterial infections (SBIs) in infants with fever without source.
  • To identify clinical and laboratory predictors for SBIs in this population.

Main Methods:

  • A retrospective study of 137 infants aged 0-36 months with fever without source (January 2015 - December 2017).
  • Analysis of demographic, clinical, and laboratory data to compare patients with and without SBIs.
  • Evaluation of potential predictors for SBIs.

Main Results:

  • Serious bacterial infections were diagnosed in 29.9% of infants.
  • Urinary tract infection was the most common SBI (78%).
  • Elevated C-reactive protein (>80 mg/L) and longer fever duration were significantly associated with SBIs.

Conclusions:

  • The majority of infants with fever without source do not have serious bacterial infections.
  • C-reactive protein levels and duration of fever are key indicators for identifying SBIs.
  • Further validation in diverse tropical settings is recommended.
Abstract

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