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Updated: Aug 27, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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The relationship between adjuvant chemotherapy and thiol-disulfide compounds

Pınar Akyol1, Didem Şener Dede2, Burak Bilgin3

  • 1Department of Hematology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Journal of Cancer Research and Therapeutics
|September 23, 2022
PubMed
Summary

Chemotherapy (CT) disrupts thiol balance in cancer patients, increasing oxidative stress. This study observed a shift towards disulfide levels and elevated oxidative stress after CT sessions in breast, ovarian, and endometrial cancer patients.

Keywords:
Chemotherapydisulfidenative thioloxidative stresstotal thiol

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