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Updated: Aug 27, 2025

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Radiochemical Quality Control Methods for Radium-223 and Thorium-227 Radiotherapies.

Abbie Hasson1,2, Wen Jiang3, Nadia Benabdallah2,4

  • 1Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA.

Cancer Biotherapy & Radiopharmaceuticals
|September 23, 2022
PubMed
Summary
This summary is machine-generated.

Novel radiopharmaceuticals using complex emitters like thorium-227 (227Th) and radium-223 (223Ra) require robust quality control. This study evaluates common instruments for characterizing these radionuclides, aiding in the development of alpha particle therapies.

Keywords:
quality controlradio-thin layer chromatographyα particle therapyγ counter

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Area of Science:

  • Nuclear medicine
  • Radiopharmaceutical chemistry
  • Medical physics

Background:

  • Radiopharmaceuticals typically undergo single radioactive decay, but complex emitters with multiple daughter radionuclides are emerging.
  • Quality control for these novel agents, particularly assessing chemical and radiopurity, is an active area of research.
  • Characterizing complex emitters like Thorium-227 (227Th) and Radium-223 (223Ra) is crucial for their clinical application.

Purpose of the Study:

  • To develop and evaluate novel quality control methods for characterizing 227Th and 223Ra.
  • To assess the suitability of common quality control instrumentation for analyzing complex emitters.
  • To verify the purity of a novel 227Th-labeled protein construct using the evaluated methods.

Main Methods:

  • Evaluation of a radio-TLC scanner, a gamma counter, and a solid-state alpha particle spectral imaging camera.
  • Characterization and differentiation of 227Th and 223Ra using the selected instruments.
  • Purity assessment of a 227Th-labeled protein construct.

Main Results:

  • The gamma counter and alpha camera successfully distinguished 227Th from 223Ra, enabling quantitative radionuclidic purity determination.
  • Radio-TLC showed limited purity assessment capabilities, though alpha-particle-specific settings improved resolution.
  • All three methods could differentiate between pure and impure 227Th-labeled protein constructs.

Conclusions:

  • The evaluated quality control methods provide a framework for assessing 227Th and 223Ra.
  • These techniques are applicable in both research and clinical settings for the development of alpha particle therapies.
  • Gamma counters and alpha cameras offer rapid and quantitative analysis for complex radiopharmaceuticals.