Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

7.5K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.5K
Fluid Mosaic Model01:19

Fluid Mosaic Model

12.3K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial for the Special Issue on Advances in Microfluidic Chips for Chemical and Biomedical Applications.

Micromachines·2026
Same author

Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials.

Micromachines·2025
Same author

High-throughput nanoparticle manipulation <i>via</i> controlled electro-elasticity and Joule heating in microchannels.

Lab on a chip·2025
Same author

Diffusion of Submicron Particles on Biological Surfactant Monolayers Governed by the Viscoelasticity and Interfacial Dynamics.

The journal of physical chemistry. B·2025
Same author

Lung-on-a-chip: From design principles to disease applications.

Biomicrofluidics·2025
Same author

TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.

NPJ microgravity·2025

Related Experiment Video

Updated: Aug 27, 2025

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
07:54

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

Published on: October 15, 2015

8.2K

Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers.

Yang Liu1,2, Xu Zheng1, Dongshi Guan1

  • 1State Key Laboratory of Nonlinear Mechanics (LNM), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.

ACS Nano
|September 23, 2022
PubMed
Summary
This summary is machine-generated.

Heterogeneous nanostructures in dipalmitoylphosphatidylcholine (DPPC) membranes cause anomalous diffusion. This study reveals two distinct membrane viscosities, impacting cell functions and drug delivery.

Keywords:
Anomalous diffusionAnomalous yet BrownianHeterogeneityLipid membraneNanodomain

More Related Videos

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.4K

Related Experiment Videos

Last Updated: Aug 27, 2025

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
07:54

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

Published on: October 15, 2015

8.2K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.4K

Area of Science:

  • Membrane biophysics
  • Soft matter physics
  • Statistical mechanics

Background:

  • Diffusion and mobility in biomembranes are vital for cellular functions.
  • Complex membrane structures lead to ambiguous diffusion mechanisms.
  • Understanding lipid bilayer dynamics is crucial for biological processes.

Purpose of the Study:

  • Investigate anomalous diffusion in dipalmitoylphosphatidylcholine (DPPC) monolayers.
  • Clarify the impact of heterogeneous nanostructures and condensed nanodomains.
  • Renew the understanding of hydrodynamic descriptions and diffusion statistics in lipid monolayers.

Main Methods:

  • Analysis of multistage mean square displacement (MSD).
  • Characterization of diffusion dynamics at different time scales.
  • Investigation of displacement probability distribution (DPD).

Main Results:

  • Identified a universal multistage MSD with an intermediate crossover.
  • Revealed two distinct membrane viscosities: short-time (local fluidity) and long-time (global phase).
  • Observed an 'anomalous yet Brownian' phenomenon with a double-peaked DPD, linked to dipolar forces from nanodomains.

Conclusions:

  • Heterogeneous nanostructures significantly influence membrane diffusion.
  • Findings provide insights into membrane transport, essential for cell function and drug delivery.
  • The study offers a renewed hydrodynamic and statistical framework for understanding diffusion in lipid monolayers.