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An observation-first strategy for liver injuries with "blush" on computed tomography is safe and effective
Jason M Samuels1, Heather Carmichael, Robert McIntyre
1From the Department of Surgery University of Colorado School of Medicine and Department of Trauma Service, University of Colorado Hospital, Anschutz Medical Campus (J.M.S., H.C., R.M.J., S.U., C.V.), Aurora, CO; Department of Surgery, UCSF-Fresno (S.B., R.C.D.), Fresno, CA; Trauma, Critical Care and Acute Care Surgery, Grant Medical Center (M.C.S., A.L.R.), Columbus, OH; Department of Surgery, University of California, San Francisco (M.S.F.), San Francisco, CA; Departments of Emergency Medicine and Surgery, Program in Trauma, R Adams Cowley Shock Trauma Center (D.M.S., D.J.H., H.A.), University of Maryland School of Medicine, Baltimore, MD; Graduate Medical Education, Methodist Dallas Medical Center (M.S.T., H.M.G.V.), Dallas, TX; Division of Trauma, Acute Care Surgery and Surgical Critical Care, Department of Surgery, Spartanburg Regional Medical Center (C.J.M., T.J.M.), Spartanburg, SC; Department of Surgery, University of Calgary (C.G.B.), Calgary, Alberta; Division of Acute Care Surgery, Loma Linda University Medical Center (K.M., G.M.), Loma Linda, CA; Department of Surgery (H.A.), University of Maryland School of Medicine, Baltimore MD; Department of Trauma and Acute Care Surgery, UCHealth Memorial Hospital (T.J.S., J.R.), Colorado Springs, CO; Department of Surgery, University of California Irvine (J.N., E.T.), Orange, California; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem (M.B.), Jerusalem, Israel; Division of Trauma, Acute Care Surgery and Surgical Critical Care, Banner-University Medical Center Phoenix (N.K., M.C.), Phoenix, AZ; Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center (N.K.D., E.J.L.), Los Angeles, CA; Department of Surgery, Cooper University Hospital (T.E., J.W.), Camden, NJ; Department of Surgery and Perioperative Care, Dell Medical School (T.C.P.C., V.E.), University of Texas at Austin, Austin, TX; Department of Surgery, Division of Trauma Acute Care Surgery, Banner Thunderbird Medical Center (K.P., K.C.), Glendale, AZ; Division of Trauma and Surgical Critical Care, Department of Surgery (S.B., F.S.E.), Rutgers New Jersey Medical School, Newark, NJ; Department of Trauma and Acute Care Surgery, Medical Center of the Rockies (W.D., C.P.), Loveland, CO; Department of Surgery, Denver Health Medical Center (N.L.W.), Denver, CO; Department of Trauma, Ascension Via Christi Saint Francis (J.M.H., K.L.), Wichita, KS; Department of Surgery, Miami Valley Hospital (G.S.), Wright State University, Dayton, OH; Department of Surgery, Prisma Health-Upstate (K.S.), Greenville, SC; and Department of Surgery, Boulder Community Hospital (L.A.H.), Boulder, CO.
Introduction:
The management of liver injuries in hemodynamically stable patients is variable and includes primary treatment strategies of observation (OBS), angiography (interventional radiology [IR]) with angioembolization (AE), or operative intervention (OR). We aimed to evaluate the management of patients with liver injuries with active extravasation on computed tomography (CT) imaging, hypothesizing that AE will have more complications without improving outcomes compared with OBS.
Methods:
This is a prospective, multicenter, observational study. Patients who underwent CT within 2 hours after arrival with extravasation (e.g., blush) on imaging were included. Exclusion criteria included cirrhosis, nontraumatic hemorrhage, transfers from outside facilities, and pregnancy. No hemodynamic exclusion criteria were used. The primary outcome was liver-specific complications. Secondary outcomes include length of stay and mortality. Angioembolization patients were compared with patients treated without AE. Propensity score matching was used to match based on penetrating mechanism, liver injury severity, arrival vital signs, and early transfusion.
Results:
Twenty-three centers enrolled 192 patients. Forty percent of patients (n = 77) were initially OBS. Eleven OBS patients (14%) failed nonoperative management and went to IR or OR. Sixty-one patients (32%) were managed with IR, and 42 (69%) of these had AE as an initial intervention. Fifty-four patients (28%) went to OR+/- IR. After propensity score matching (n = 34 per group), there was no difference in baseline characteristics between AE and OBS. The AE group experienced more complications with a higher rate of IR-placed drains for abscess or biloma (22% vs. 0%, p = 0.01) and an increased overall length of stay ( p = 0.01). No difference was noted in transfusions or mortality.
Conclusion:
Observation is highly effective with few requiring additional interventions. Angioembolization was associated with higher rate of secondary drain placement for abscesses or biloma. Given this, a trial of OBS and avoidance of empiric AE may be warranted in hemodynamically stable, liver-injured patient with extravasation on CT.
Level Of Evidence:
Therapeutic/Care Management; Level II.
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