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Updated: Aug 27, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
The adventitia in arterial development, remodeling, and hypertension
Mark W Majesky1, Mary C M Weiser-Evans2
1Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA; the Departments of Pediatrics, Seattle, WA 98101, USA; and Laboratory Medicine & Pathology, Seattle, WA 98195, USA; Center for Cardiovascular Biology, Seattle, WA 98195, USA.
Abstract:
The adventitia receives input signals from the vessel wall, the immune system, perivascular nerves and from surrounding tissues to generate effector responses that regulate structural and mechanical properties of blood vessels. It is a complex and dynamic tissue that orchestrates multiple functions for vascular development, homeostasis, repair, and disease. The purpose of this review is to highlight recent advances in our understanding of the origins, phenotypes, and functions of adventitial and perivascular cells with particular emphasis on hypertensive vascular remodeling.
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