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Updated: Aug 27, 2025

Light/dark Transition Test for Mice
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Published on: November 13, 2006

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Shot in the dark.

M Tariq Bhatti1, Aubrey L Gilbert2, George Watson3

  • 1Department of Ophthalmology, The Permanente Medical Group, Roseville, CA, USA.

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|September 23, 2022
PubMed
Summary
This summary is machine-generated.

A rare case of bilateral optic neuritis occurred after the Pfizer-BioNTech COVID-19 vaccine. Prompt treatment with steroids and plasma exchange led to vision recovery, though visual field defects persisted.

Keywords:
COVID-19SARS-CoV-2adverse eventautoimmunityoptic neuritisvaccine

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Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Optic neuritis, inflammation of the optic nerve, can cause vision loss.
  • Post-vaccination neurological complications are rare but warrant investigation.

Observation:

  • A 43-year-old woman developed bilateral optic neuritis 10 days post-Pfizer-BioNTech COVID-19 vaccination.
  • Symptoms included decreased vision and painful eye movements, progressing to severe vision loss.

Findings:

  • Clinical and MRI findings indicated optic perineuritis progressing to optic neuritis.
  • Extensive autoimmune and infectious workups were negative.
  • Nadir visual acuity was counting fingers, improving to 20/20 with treatment.

Implications:

  • This case highlights a potential, albeit rare, association between COVID-19 vaccination and optic neuritis.
  • Early intervention with steroids and plasma exchange can improve visual outcomes.
  • Persistent visual field defects and optic disc pallor underscore the severity and potential long-term sequelae.