Related Experiment Video

Updated: Aug 27, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.1K

Antibiotic treatment duration in diverticulitis, complicated urinary tract infection, and endocarditis: a

Nicolas Eduard Frei1, Sarah Dräger2, Maja Weisser3

  • 1Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|September 23, 2022
PubMed

Insights

Antibiotic treatment durations for diverticulitis and complicated urinary tract infections (UTIs) often exceed guidelines, unlike endocarditis. This study highlights poor adherence to antibiotic treatment guidelines for common infections.

Area of Science:

  • Infectious Diseases
  • Clinical Pharmacy
  • Antimicrobial Stewardship

Background:

  • International guidelines recommend shorter antibiotic durations for infections like diverticulitis and complicated urinary tract infections (UTIs).
  • Nonadherence to these guidelines is frequently observed in clinical practice.
  • Assessing adherence is crucial for optimizing antimicrobial therapy and patient outcomes.

Purpose of the Study:

  • To evaluate the adherence to international and local guidelines for antibiotic treatment duration.
  • To analyze treatment durations for diverticulitis, complicated UTIs, and endocarditis.

Main Methods:

  • Retrospective review of medical records from 2017-2018 at a Swiss tertiary care hospital.
  • Inclusion of 243 patients: 100 with diverticulitis, 200 with complicated UTIs, and 43 with endocarditis.
  • Assessment of antibiotic treatment appropriateness against established guidelines.

Main Results:

  • Adherence rates were low for diverticulitis (11-18%) and complicated UTIs (39-40%), with prolonged treatments.
  • Endocarditis showed high adherence (84-86%).
  • Pathogen identification, medical ward hospitalization, and infectious diseases consultation were linked to better adherence in diverticulitis and complicated UTIs.

Conclusions:

  • Prolonged antibiotic courses are common for diverticulitis and complicated UTIs, indicating poor guideline adherence.
  • Adherence is moderate for complicated UTIs and excellent for endocarditis.
  • Strategies to improve adherence for common infections require further investigation.
Abstract

Keywords:
AdherenceAntimicrobial stewardshipComplicated urinary tract infectionDiverticulitisDuration of antibiotic treatment

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

20.2K
Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging07:39

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging

Published on: June 14, 2021

3.1K

Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
24
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
33
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
13
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
99
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
22
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
74