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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
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Lymphoid aggregates in bone marrow: a diagnostic pitfall.

Umberto Maccio1, Anton V Rets2,3

  • 1Pathology, University Hospital Zurich, Zürich, Switzerland.

Journal of Clinical Pathology
|September 23, 2022
PubMed
Summary
This summary is machine-generated.

Distinguishing benign from malignant lymphoid aggregates in bone marrow is crucial. This review provides evidence-based criteria and discusses ancillary tests to aid pathologists in accurate diagnosis and understanding benign aggregate significance.

Keywords:
bone marrowbone marrow diseaseslymphocyteslymphoma

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Area of Science:

  • Hematopathology
  • Diagnostic Pathology

Background:

  • Lymphoid aggregates in bone marrow are common but can be diagnostically challenging.
  • Differentiating reactive from neoplastic aggregates is clinically significant.

Purpose of the Study:

  • To provide evidence-based criteria for distinguishing benign from malignant lymphoid aggregates.
  • To discuss the utility and limitations of ancillary tests in bone marrow pathology.
  • To review the etiologies and clinical associations of benign lymphoid aggregates.

Main Methods:

  • Literature review focusing on diagnostic criteria for lymphoid aggregates.
  • Analysis of ancillary testing modalities (immunohistochemistry, flow cytometry, molecular studies).
  • Synthesis of information on causes and implications of benign lymphoid aggregates.

Main Results:

  • Established criteria for differentiating reactive versus neoplastic lymphoid aggregates.
  • Evaluated advantages, disadvantages, and pitfalls of various diagnostic tests.
  • Summarized common causes of benign lymphoid aggregates, including infections and autoimmune disorders.

Conclusions:

  • Accurate distinction between benign and malignant lymphoid aggregates is essential for patient management.
  • Awareness of ancillary test limitations is critical for correct interpretation.
  • Benign lymphoid aggregates have varied clinical significance and associations requiring careful evaluation.