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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
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Herpes simplex virus-induced murine dry skin model through sweating disturbance
Yumiko Asanuma1, Hironobu Ishimaru2, Tetsuko Sato1
1Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Journal of Dermatological Science
|September 23, 2022
Summary
Herpes simplex virus 1 (HSV-1) can infect sweat glands, causing sweating disturbance and dry skin. This study developed a mouse model to investigate this link, finding HSV-1 directly impairs sweat gland function.
Area of Science:
- Dermatology
- Virology
- Immunology
Background:
- Herpes simplex virus 1 (HSV-1) keratitis leads to tear production loss.
- Sweat gland susceptibility to HSV-1 may cause sweating disturbance, common in atopic dermatitis.
- The role of sweating in skin hydration is unclear due to limited mouse models.
Purpose of the Study:
- To investigate the link between HSV-1 infection of sweat glands and dry skin.
- To establish a mouse model for studying sweating disturbance induced by HSV-1.
Main Methods:
- HSV-1 DNA detection in mouse footpad sweat glands.
- Examination of sweating response using impression mold technique post-inoculation.
- Assessment of skin hydration and response to hyperthermic stress.
Main Results:
- HSV-1 infection significantly decreased sweating response and skin hydration.
- Hyperthermic stress exacerbated HSV-1-induced sweating disturbance and dry skin.
- HSV-1 DNA was found in sweat glands and dorsal root ganglia, but nerve damage was ruled out.
Conclusions:
- Sweating disturbance results from HSV-induced sweat gland dysfunction, not nerve damage.
- A novel mouse model for HSV-1-induced sweating disturbance and dry skin was successfully developed.
