Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postoperative Pain Control After Cesarean Section by Continuous Infusion Pump System Versus Ropivacaine Hydrogel: A Prospective Randomized Clinical Trial.

Gels (Basel, Switzerland)·2026
Same author

Automated estimation of perivascular space and brain morphometry from deep learning-reconstructed three-dimensional T1-weighted MRI: comparison with the conventional technique.

Journal of neuroradiology = Journal de neuroradiologie·2026
Same author

Editor's Note: Essential Role of DNA Methyltransferase 1-mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Deep Learning Reconstruction on Quantitative Analysis in Brain Tumors With Diffusion-Weighted Imaging and Dynamic Susceptibility Contrast Imaging.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Uncover This Tech Term: Large Vision-Language Models in Radiology.

Korean journal of radiology·2026
Same author

Case Report: Expanding the diagnostic spectrum of non-invasive prenatal testing to structural chromosomal abnormalities.

Frontiers in genetics·2026

Related Experiment Video

Updated: Aug 27, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.5K

Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors.

Vitor Brasiliense1,2, Ji Eun Park1, Eric J Berns3

  • 1Department of Chemistry, Northwestern University, Evanston, IL-60208, USA.

Scientific Reports
|September 23, 2022
PubMed
Summary

This study introduces a novel microneedle sensor strategy using surface potential to improve Raman spectroscopy biosensing. This method enhances analyte detection by controlling molecule adsorption and enabling advanced data analysis.

More Related Videos

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.3K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.4K

Related Experiment Videos

Last Updated: Aug 27, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.5K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.3K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.4K

Area of Science:

  • Analytical Chemistry
  • Biosensing Technology
  • Spectroscopy

Background:

  • Raman spectroscopic biosensing faces challenges with low signal intensity and complex mixtures of chemical species.
  • Surface-enhanced Raman spectroscopy (SERS) offers signal enhancement but relies on specific analyte adsorption, limiting general applicability.
  • Existing methods struggle to differentiate between multiple analytes and mitigate confounding factors like surface reactions and competitive adsorption.

Purpose of the Study:

  • To develop a new strategy for Raman spectroscopic biosensing that overcomes limitations of low signal and analyte complexity.
  • To utilize surface potential as a physical binding agent in microneedle sensors for improved analyte detection.
  • To enable the differentiation and selective measurement of analytes in complex mixtures and the presence of interferants.

Main Methods:

  • Development of microneedle sensors incorporating surface potential control.
  • Exploitation of potential-dependent adsorption and desorption of chemical species.
  • Application of multivariate analysis methods to spectral data obtained through cyclic adsorption/desorption.

Main Results:

  • Demonstrated that surface potential effectively controls the adsorption of different chemical species onto the sensor surface.
  • Showcased the ability to scrutinize individual chemical contributions to the overall Raman spectrum.
  • Successfully mitigated confounding phenomena including surface reactions, competitive adsorption, and interference from structurally similar molecules.

Conclusions:

  • Surface potential-based microneedle sensors offer a robust strategy to enhance Raman spectroscopic biosensing.
  • The method allows for effective decomposition of complex spectra, improving analyte quantification in the presence of interferants.
  • This approach provides new opportunities for maximizing target analyte signals and advancing biosensing capabilities.