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Reference values for diaphragm electrical activity (Edi) in newborn infants.

Varappriyangga Gurumahan1, Sriganesh Thavalingam1, Tim Schindler1,2

  • 1School of Women's and Children's Health, University of New South Wales, Sydney, Australia.

BMC Pediatrics
|September 23, 2022
PubMed
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Reference values for the electrical activity of the diaphragm (Edi) were established in neonates. These Edi values aid in monitoring and utilizing diaphragm-triggered respiratory support for infants.

Area of Science:

  • Neonatal physiology
  • Respiratory support
  • Diaphragm electrical activity

Background:

  • Neurally adjusted ventilatory assist (NAVA) uses diaphragm electrical activity (Edi) for synchronized inspiratory support.
  • Limited data exists on Edi reference values in neonates.
  • Establishing these values is crucial for optimizing respiratory support.

Purpose of the Study:

  • To establish reference Edi values for both preterm and term neonates.
  • To provide a baseline for Edi monitoring in infants not receiving respiratory support.

Main Methods:

  • Prospective observational study of spontaneously breathing neonates.
  • Edi waveform monitored using a naso/orogastric tube with embedded electrodes.
  • Continuous Edi recording for 4 hours without altering clinical care.
Keywords:
DiaphragmIntensive care unitsNeonatalNon-invasive ventilation

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Main Results:

  • Twenty-four infants (16 preterm, 8 term) were studied.
  • Mean Edi minimum: 3.02 ± 0.94 μV; Mean Edi peak: 10.13 ± 3.50 μV.
  • Preterm infants: Mean Edi minimum 3.05 ± 0.91 μV, Mean Edi peak 9.36 ± 2.13 μV.
  • Term infants: Mean Edi minimum 2.97 ± 1.05 μV, Mean Edi peak 11.66 ± 5.14 μV.

Conclusions:

  • Reference Edi values were successfully established for preterm and term neonates.
  • These values serve as a guide for monitoring breathing support.
  • Facilitates the use of diaphragm-triggered respiratory support in neonates.