[Molecular and biological aspects of Arterivirus]

Arteriviruses are a group of small enveloped viruses with a genome composed of a positive, single-stranded, 5'-capped and 3'-polyadenylated RNA molecule. These viruses belong to the Arteriviridae family which together with the Coronaviridae and Roniviridae families constitutes the order Nidovirales. Arteriviruses have a marked tropism for macrophages and induce persistent infections. Several studies have reported the unique genomic organization of these viruses together with replication and transcription mechanisms for the synthesis of genomic and sub-genomic viral RNAs which, for the latter, encode viral structural proteins. Several sequences are now available for these viruses. Recent studies about the modulation of innate immune response by arteriviruses also demonstrated a key-role of particular non structural proteins in that process. Finally, certain pro- and anti-apoptotic mechanisms associated to Arteriviruses have been elucidated; however the exact significance of theses apoptotic processes in arterivirus pathogenesis has yet to be determined.