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[SUMO in the viral world].

Audrey Coiffic1, Guillaume Beauclair1, Alessia Zamborlini1

  • 1Inserm U944-CNRS UMR 7212, Université Paris-Diderot, Institut universitaire d'hématologie, 1, avenue Claude-Vellefaux, 75475 Paris Cedex 10, France.

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Summary
This summary is machine-generated.

Viruses hijack cellular SUMOylation (small ubiquitin-like modifier) pathways to enhance viral replication. This review explores viral strategies, associated pathologies, and potential therapeutic applications of SUMOylation inhibitors.

Keywords:
SUMOSUMO E3 ligasesSUMOylationUbc9virus

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Area of Science:

  • Molecular Biology
  • Virology
  • Biochemistry

Context:

  • Post-translational modifications regulate cellular processes.
  • Viruses exploit host cell machinery for replication.
  • SUMOylation is a key regulatory modification.

Purpose:

  • To review how viruses manipulate SUMOylation for replication.
  • To discuss the link between viral infections, pathologies, and SUMOylation.
  • To explore therapeutic potential of SUMOylation inhibitors.

Summary:

  • Viruses utilize SUMOylation (small ubiquitin-like modifier) pathways to modulate viral protein function, localization, and stability, thereby promoting replication.
  • Numerous viruses either exploit or interfere with host SUMOylation processes.
  • This review highlights viral strategies for hijacking SUMOylation and discusses associated disease pathologies.

Impact:

  • Provides insights into viral pathogenesis mechanisms.
  • Identifies potential therapeutic targets for viral infections.
  • Suggests novel strategies for treating viral diseases and associated cancers.