Virtual Reverse Screening Approach to Target Type 2 Cannabinoid Receptor

A screening pool consisting of 617710 drug-like query molecules properly filtered from the ChEMBL database was employed for a ligand-based reverse screening toward the type 2 cannabinoid receptor (CB₂) target. By using our recently developed PLATO polypharmacological web platform, 233 out of 617710 drug-like molecules were prioritized on the basis of the predicted bioactivity values, better than 0.2 μM with a probability of about 98%, toward the CB₂ target. Building on these results, the occurrence of putative CB₂-related targets was also investigated for prospective repurposing studies.