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Gut microbiome in multiple sclerosis-related cognitive impairment
Fereshteh Ghadiri1, Zahra Ebadi1, Elnaz Asadollahzadeh1
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis and Related Disorders
|September 24, 2022
Summary
The gut microbiome may impact cognition, particularly in multiple sclerosis (MS) patients. Further research into brain-gut axis interventions like diet or probiotics could help cognitive impairment in MS.
Area of Science:
- Neurology
- Microbiology
- Neuroimmunology
Background:
- Cognition is frequently assessed in neurological disorders.
- Cognitive impairment is a common issue for multiple sclerosis (MS) patients.
- The gut microbiome is increasingly recognized for its role in neurological health.
Purpose of the Study:
- To review current evidence linking gut microbiota to cognition in multiple sclerosis.
- To explore potential therapeutic strategies targeting the brain-gut axis for MS-related cognitive deficits.
Main Methods:
- Literature review of studies on gut microbiome, cognition, and multiple sclerosis.
- Synthesis of indirect evidence to hypothesize potential benefits of interventions.
Main Results:
- No direct studies currently link gut microbiota to cognition in MS.
- Indirect evidence suggests a potential role for the gut microbiome in MS cognitive function.
Conclusions:
- Interventions targeting the brain-gut axis, such as dietary changes, probiotics, or microbiota transplantation, may offer hypothetical benefits for cognitive impairment in MS.
- Further research is needed to investigate these potential therapeutic avenues and fill existing knowledge gaps.
