Perovskite quantum dots as a chemiluminescence platform for highly sensitive assay of cefazolin

This paper reports on a chemiluminescence (CL) probe consist of CsPbBr₃ quantum dots (QDs) in organic phase together with Fe(II) and K₂S₂O₈ in aqueous medium for the highly selective and sensitive determination of the antibiotic, cefazolin (CFZ). The CsPbBr₃perovskite QDs prepared by the ligand assisted reprecipitation method, exhibit a narrow fluorescence at 533 nm under 460 nm excitation with a high quantum yield (42 %). The Fe(II) - S₂O₈^2- as an ultra-weak CL system is converted to a rather strong CL sensing platform in the presence of organic-phase CsPbBr₃ QDs. It was observed that CFZ exerts an enhancement effect on the CL signal of the designed probe in the linear range of 25 - 300 nM, with a low limit of detection (9.6 nM). The introduced sensor has broad application prospects in biosensing, food detection, and other fields with recovery ranging from 94 to 106 %.