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Screening tools for work-related asthma and their diagnostic accuracy: a systematic review protocol
Ngamjit Kongsupon1, Gareth I Walters2,3, Peymané Adab2
1Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK nxk798@student.bham.ac.uk.
BMJ Open
|September 24, 2022
Summary
Work-related asthma (WRA) screening tools need better evaluation for early detection. This systematic review compares the performance of various WRA screening methods to improve health and employment outcomes for affected workers.
Area of Science:
- Occupational Medicine
- Respiratory Medicine
- Public Health
Background:
- Work-related asthma (WRA) significantly impacts adult health, work, and income, yet is often undiagnosed.
- Early identification of WRA is crucial for improved health and employment outcomes.
- Current screening tools for WRA lack established optimal use and effectiveness data.
Purpose of the Study:
- To systematically review and compare the performance of screening tools for identifying work-related asthma (WRA).
- To evaluate screening tools in both clinical and workplace settings.
- To inform best practices for WRA detection.
Main Methods:
- Systematic review of observational and experimental studies (1975-2021).
- Comprehensive database search (MEDLINE, EMBASE, CINAHL Plus, Web of Science, etc.) and grey literature review.
- Data extraction and quality assessment using the Quality Assessment of Diagnostic Test Accuracy 2 tool; meta-analysis where appropriate.
Main Results:
- Performance metrics (sensitivity, specificity) of various WRA screening tools will be summarized.
- Heterogeneity will be assessed using subgroup analyses and meta-analysis with a bivariate random effect model if studies are homogenous.
- Findings will be presented via paired forest plots and summary receiver operating characteristic curves.
Conclusions:
- This systematic review will provide a comprehensive comparison of WRA screening tool performance.
- Results aim to guide the selection of optimal screening strategies for WRA.
- Evidence generated will support improved detection and management of WRA in occupational and clinical settings.
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