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Updated: Aug 27, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Circ_0051079 functions as an oncogenic regulator in osteosarcoma by leading to MAFB expression upregulation by

Zhong Huang1, Pengcheng Chen1, Ruipeng Jia1

  • 1Orthopedic Center, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou City, 570208, Hainan, China.

Journal of Orthopaedic Surgery and Research
|September 24, 2022
PubMed
Abstract

Insights

Circular RNA circ_0051079 promotes osteosarcoma (OS) progression by regulating the miR-1286/MAFB axis. Inhibiting circ_0051079 suppressed tumor growth, proliferation, and metastasis in OS.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) play crucial roles in bone diseases, including osteosarcoma (OS), by regulating gene expression.
  • This study investigates the specific molecular mechanism of circ_0051079 in the progression of osteosarcoma.

Purpose of the Study:

  • To elucidate the role of circ_0051079 in osteosarcoma (OS) progression.
  • To investigate the molecular mechanism involving circ_0051079, microRNA-1286 (miR-1286), and musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) in OS.

Main Methods:

  • Quantitative real-time PCR for gene expression analysis.
  • Cell proliferation, apoptosis, migration, and invasion assays were performed.
  • Dual-luciferase reporter assays and in vivo tumor xenograft models were utilized to confirm interactions and effects.

Main Results:

  • Circ_0051079 expression was significantly upregulated in osteosarcoma tissues.
  • Downregulation of circ_0051079 inhibited OS cell proliferation, migration, invasion, and induced apoptosis.
  • The circ_0051079/miR-1286/MAFB axis was confirmed to regulate osteosarcoma progression, with circ_0051079 promoting MAFB expression via sponging miR-1286.

Conclusions:

  • Circ_0051079 acts as a key driver in osteosarcoma progression.
  • The findings highlight the circ_0051079/miR-1286/MAFB axis as a potential therapeutic target for osteosarcoma treatment.
Keywords:
MAFBOsteosarcomacirc_0051079miR-1286

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