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Targeting the (pro)renin receptor in cancers: from signaling to pathophysiological effects

Xin Ouyang1, Chuanming Xu2

  • 1Qihuang TCM Academy, Jiangxi University of Chinese Medicine, Nanchang, 330004, China.

Journal of Cancer Research and Clinical Oncology
|September 25, 2022
PubMed

Insights

The (pro)renin receptor (PRR) shows promise as a biomarker for various cancers. Targeting PRR offers potential for improved cancer diagnosis, treatment, and prognosis.

Area of Science:

  • Oncology
  • Biomarker Discovery
  • Molecular Biology

Background:

  • Cancer poses a significant global health challenge with unpredictable clinical outcomes.
  • Lack of reliable biomarkers for cancer progression contributes to treatment unpredictability.
  • The (pro)renin receptor (PRR) has emerged as a potential biomarker in multiple cancer types.

Purpose of the Study:

  • To systematically review the current research on targeting the (pro)renin receptor (PRR) in cancer.
  • To understand the relationship between PRR expression and various cancers.
  • To explore PRR's role in cancer signaling, pathophysiology, and treatment.

Main Methods:

  • Literature review of studies investigating PRR in different cancer types.
  • Analysis of PRR/soluble PRR (sPRR) expression levels in relation to cancer.
  • Examination of proposed mechanisms of PRR in cancer progression.
  • Review of PRR-targeted cancer therapies.

Main Results:

  • PRR expression correlates with various cancers including colorectal, breast, glioma, and pancreatic ductal adenocarcinoma.
  • PRR influences cancer progression through diverse signaling pathways.
  • PRR's role in aldosterone-producing adenoma, endometrial, and urothelial cancers is highlighted.

Conclusions:

  • The (pro)renin receptor (PRR) is a promising novel biomarker for cancer.
  • Targeting PRR presents potential therapeutic strategies for cancer diagnosis, treatment, and prognosis.
  • Further clinical development and application of PRR in oncology are warranted.
Keywords:
(Pro)renin receptorCancerPRRRenin–angiotensin system

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