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The impact of birth weight and gestational age on acute mastoiditis in children
Elchanan Zloczower1, Noam Bartov2, Raviv Allon2
1Department of Otolaryngology-Head and Neck Surgery, Kaplan Medical Center, Hadassah Medical School, The Hebrew University of Jerusalem, Rehovot, Israel. chanani9@gmail.com.
Insights
Low birth weight (LBW) and preterm birth do not increase acute mastoiditis (AM) severity or complications. However, LBW infants develop AM later, and preterm infants experience recurrent AM more frequently.
Area of Science:
- Pediatrics
- Otolaryngology
- Neonatology
Background:
- Previous studies link preterm birth and low birth weight (LBW) to acute otitis media.
- The relationship between LBW/preterm birth and acute mastoiditis (AM) requires further investigation.
Purpose of the Study:
- To examine the impact of LBW and preterm birth on AM severity.
- To assess neuro-otological complications and recurrence rates in infants with AM.
- To identify distinct disease courses in LBW and preterm infants with AM.
Main Methods:
- Retrospective cohort study of 294 children diagnosed with AM between 1999 and 2020.
- Data collected included gestational age, birth weight, clinical presentation, laboratory results, imaging, and long-term outcomes.
- Comparison between LBW/preterm infants and normal birth weight/gestational age infants.
Main Results:
- No significant differences in AM severity, laboratory findings, imaging, or late complications were observed between LBW and normal birth weight (NBW) groups, or between preterm and normal gestational age groups.
- LBW children were diagnosed with AM at a statistically older age (2.28 years) compared to NBW children (1.84 years).
- Preterm infants showed a higher propensity for recurrent AM episodes with shorter intervals between events.
Conclusions:
- LBW and preterm birth are not independent risk factors for increased AM severity, intervention needs, or future complications.
- LBW infants present with AM at an older age, and preterm infants are more susceptible to recurrent AM, indicating unique disease trajectories.
Objective:
Previous data correlate preterm and low birth weight (LBW) with acute otitis media, but there is a gap concerning the relations with acute mastoiditis (AM). This study investigates the effect of LBW and preterm birth on AM disease severity, neuro-otological complications, and recurrence.
Study Design:
Retrospective cohort.
Setting:
Tertiary medical center.
Methods:
The cohort is retrospective in nature consisting of 294 children with AM admitted between 1999 and 2020. Data collection included: patient gestational age and birth weight, signs and symptoms, physical examination, laboratory tests, imaging findings, and long-term outcomes.
Results:
294 cases of AM were included, 41/281 (15%) had LBW (< 2500 g), and 46/294 (15.7%) were preterm (gestational age < 37 weeks). We found no significant differences in laboratory tests, imaging studies (CT), rate of mastoidectomy performed, or late complications between LBW and normal birth weight (NBW) and between preterm and normal gestational age children. LBW children tended to develop AM at an older age compared with NBW children, 2.28 + 1.64 Vs. 1.84 + 1.4 years, respectively (p-value = 0.016). Additionally, preterm children were more prone to develop a second event of AM, with a shorter interval between these episodes.
Conclusions:
LBW and preterm birth are not independent risk factors for disease severity, need for intervention, or future complications in AM. Yet, LBW children present with AM at an older age, and preterm children are more prone for recurrent episodes of AM with a shorter interval between episodes suggesting a distinct disease course in these populations.
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